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Finally, our results demonstrate that androgen signaling serves as a potent stimulating signal driving HHEX expression in the adrenal at puberty, but other hormonal factors, such as estrogens, might also influence adrenal functions and were not addressed in the current study

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Strong family history of heart disease and stroke

Dermatomyositis most commonly occurs in children between 5 and 15 years old, or adults in their late 40s to early 60s

Microglial ferroptosis can activate neurotoxic astrocytes through pro-inflammatory signaling, and ferroptosis-related genes such as ALOX5/15 are highly enriched in microglia, yet this study does not establish whether ferroptosis is upstream in the cascade involving mitochondrial complex IV defects, oxidative stress, and neuroinflammation