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The Nakayama Alzheimer's disease study demonstrated that cognitive function in older adults, including controls, patients with mild cognitive impairment, and those with AD, was linked to alterations in plasma metabolites such as reduced levels of lysine, ornithine, and uracil (Ozaki et al., 2022)

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In stage 5 , the eGFR is less than 15

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Toxicol Appl Pharmacol 204:329342 Sun X, Shih AY, Johannssen HC, Erb H, Li P, Murphy TH (2006) Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering in developing neurons and cells at the cerebrospinal fluid and blood-brain interface