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Most of these previous trials were conducted in a select group of patients with the following characteristics: 1) predominantly receiving complete nutrition support via PN, 2) common exclusion of renal and liver failure based on glutamine product prescribing restrictions, 3) GLN supplementation of PN is often initiated later in the ICU stay (not at ICU admission during the shock phase), as PN is typically started later in the stay when enteral nutrition (EN) is not possible or meeting nutritional needs, 4) enrollment of oncology patients who may be at a greater risk for tumor-mediated GLN depletion, 5) use of GLN dose between 0.3 g/kg/day to a maximum of 0.5 g.kg/day given only via the intravenous route

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Lipids Health Dis (2011) 10:177.10.1186/1476-511X-10-177 52 PalombellaVJRandoOJGoldbergALManiatisT

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