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BMC Complementary and Alternative Medicine, 19 (1), 114

Although improved bioavailability by itself should not be equated with demonstrated clinical efficacy nanoformulation undoubtedly offers pharmacotechnical advantages especially for poorly soluble phytochemicals

Reducing the amount of solely soybean oil-based ILE from 23 to 1 g/kg/day [90] or substituting it with fish oil-based ILE at 1 g/kg/day or with ILEs based on a mixture of several oils, including fish oil at the maximum dose of 23 g/kg/day [91] are experimentally proven methods that can reverse cholestasis in infants with IFALD

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Melatonin, which upregulates the expression of ATP7B and GPX4 in cumulus cells, may be particularly beneficial individuals with genetic variants that disrupt metal ion homeostasis or lipid peroxidation defenses (Tsui et al., 2024)