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Absorption efficiency differences remain the main factor affecting outcome variability, with injection methods producing reliable pharmacokinetic behavior in laboratory settings

10.1038/nrmicro2384 20

Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging

Simply put, this means that Roux-en-Y patients dont absorb B-12 very well from a simple swallow pill

Second, given the complexity of PD pathogenesis, developing multi-target synergistic therapies capable of simultaneously intervening in multiple critical pathways is particularly crucial