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Discovery and development of MEDI7247, a novel pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2, for treating hematological cancers

Notably, despite the dramatic difference in d 3 -TMAO production from oral d 3 -l-carnitine in omnivores versus vegans/vegetarians, the difference observed in the first step of that gut microbiotamediated transformation, conversion of d 3 -l-carnitine to d 3 -BB, was not significant, and if anything showed a trend toward a lower conversion rate in the omnivores ( P = 0.051

To measure the level of total carnitine, the obtained supernatant was mixed with 1 M KOH in an Eppendorf tube and kept at 37 C for 20 min for the degradation of acylcarnitines

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