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Key structural features include: Alanine at position 2: Confers DPP-4 resistance (vs

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Earlier phase 1 and 2 studies demonstrated that cagrilintide was well-tolerated, exhibiting a safety profile consistent with FDA-approved GLP-1 receptor agonists like semaglutide and liraglutide, as well as the amylin analog pramlintide [1]

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Tirzepatide was administered at a dose assumed to be below the lowest clinically applicable dose of 5 mg, based on C max [46], and the same dose was used for retatrutide