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NF-B activation mediated by ER stress is dependent on Ca 2+ efflux and subsequent production of reactive oxygen species (ROS) ( The NF-B and ER stress in atherosclerosis Three stages of atherosclerosis progression Atherosclerosis is a common chronic inflammatory disease characterized by the accumulation of fibrin and lipids in subendothelial space, being a leading cause of cardiovascular diseases, including heart failure, stroke, and claudication ( Loss of intact endothelial functions occurs at the earliest in atherogenesis, followed by lipid accumulation and fatty streak formation under the endothelial cells

Ferrari E, Barbero F, Busquets-Fit M, Franz-Wachtel M, Khler H-R, Puntes V, et al