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Methods/design The proposed study involves a controlled, randomised, multicentre, parallel, non-inferiority clinical trial lasting one year, involving 23 primary healthcare centres in the Madrid region (Spain), and patients 65 years of age

the inventors also surprisingly found inhibitory activity with certain embodiments of the invention where R 1 is methyl with dual positional substitutions (see e.g., compounds 2j, 2m, 2k, and 2l, Table 2)

When two or more independent drugs are combined, their effects add up, and the Bliss synergy score is 0 (39)

Tawakol A, Omland T, Gerhard M, Wu JT, and Creager MA (1997)

The underlying mechanism of magnesiums effects lies in its important role in preventing central sensitization, which is considered to be the primary mechanism underlying FM