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This risk is particularly concerning with chronic use or in individuals with family histories of cancer or existing malignancies

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Giliberto L (2022) Neurology evaluation in dementia and neurodegenerative disease

McMahon CD, Chai R, Radley-Crabb HG, Watson T, Matthews KG, Sheard PW, Soffe Z, Grounds MD, Shavlakadze T (2014) Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice

These ROS generate hydroxyl radicals via the Fenton reaction, which attack intracellular proteins, DNA, and lipid membranes, thereby disrupting mitochondrial function and cellular integrity, and promoting the occurrence of ferroptosis