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6 Conclusion and perspectives The pathogenesis of RA is still unclear

2000 Sep;47(3):397-403

This guide summarizes information reported in published research and community practice for educational purposes

Decreased receptor sensitivity to glucocorticoids and increased glucocorticoid exposure resulting from prolonged stress may reduce the anti-inflammatory effect of glucocorticoids, leading to persistent inflammation experienced by stressed individuals and subsequently to the development of various physical and psychological illnesses (OConnor et al., 2014)