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Description

Gamma-glutamyltransferase 1 (GGT1), a key enzyme in glutathione homeostasis, is significantly down-regulated in chRCC compared with normal kidneys, while overexpression of GGT1 can inhibit the chRCC cells proliferation, and inhibit the cystine uptake and GSH levels (125)

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Thus, NS8593 and MCC950 ameliorated the increased neuronal excitability induced by PILO, indicating that the pharmacological inhibitors of TRPM7 and NLRP3 reversed hyperexcitability in vivo