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With the publication in December, 1952 of the article Cancer by the Carton (excerpted from a polemic by Roy Norr, Smokers are Getting SCARED! in Christian Herald in October, 1952), Readers Digest began a no-holds-barred attack on cigarette smoking

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The Ames test has been used since 1973 and is still a standard test for detecting potential mutagens and carcinogens.72 Researchers have also manipulated mouse cells to make them potential targets for carcinogens and have transferred genes from cancerous cells into healthy cells and animals

Adult e-cigarette users who were never smokers had the highest rates of past quit-vaping attempts (20.9%), compared to dual users (15.3%) and former cigarette smokers (7.9%)

It often appears in rap music, movies, social media, and text conversations