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(2016) further confirmed that FMT intervention markedly altered the gut microbiota composition in PCOS rats, characterized by restored abundances of beneficial bacteria such as Lactobacillus and Clostridium to near-control levels, alongside a reduction in Prevotella

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Disclosures and sources of funding Rodney Scott and Raymond Sobel report no competing interests

Preliminary evidence indicates that IL-18 bypasses RANKL dependence in certain contexts, directly inducing osteoclast differentiation and bone destruction (Kim et al., 2015)