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Hypoxia, HIF1 and glucose metabolism in the solid tumour

Collectively, these recent contributions argue that future GSH-centric redox sensing and nanomedical approaches should (i) incorporate organelle targeting (especially mitochondria) to exploit subcellular redox heterogeneity, (ii) embed analyte-responsive activation into both therapeutic and imaging components, (iii) combine biochemical sensing with optical or thermal engineering for spatiotemporal control, and (iv) favor clinically translatable carriers (e.g., PLGA) for delivery

10731075, 1994 [16] S

In the lower range of values of S , GSH increases rapidly as S increases

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