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Significant reductions in the number of cholinergic neurons in the brain due to anesthesia and surgical factors worsened the cognitive decline associated with degeneration (Xu et al

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The values shown are the average and standard deviation from three separate experiments (n=3) (* = p-value 0.05)

Interestingly, inflammation-induced increase in zinc levels regulates inflammatory response inhibiting further IL-6 release and interfering with NF-kB activation (262) ( Figure 3A a, c)