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Previously in colon biopsies from patients affected by ulcerative colitis and Crohns disease, bromelain in vitro experiments resulted in diminished amounts of IL-2, IL-6, IL-4, G-CSF, Gm-CSF, IFN-, CCL4/macrophage inhibitory protein (MIP)-1, and TNF, implying a role in inflamed colon against pro-inflammatory cytokines and chemokines (131)

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Dramatic reduction of clindamycin plasma concentration in hidradenitis suppurativa patients treated with the rifampin-clindamycin combination

Therefore, it can not be excluded that the existence of the disulfide bridge may contribute to the formation of tetramer, while no such disulfide bridge is present in rhGPx3 mutant

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