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Hypothyroidism: There are concerns that propionyl-L-carnitine may exacerbate hypothyroidism or make treatment with thyroid hormones less effective

Mechanistically, lycopene's selective accumulation in the testes (reaching concentrations 10-fold higher than serum levels) enables direct protection of developing sperm cells from oxidative damage (201)

It is well established that glucose uptake decreases upon detachment 17,18,19 , but the main energy substrates and corresponding metabolic pathways necessary for maintaining MIC stemness under stress and initiating metastasis still need to be determined