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All structures/refinement protocols were validated by randomising the final models by applying coordinate shifts of up to 0.3 using the noise function in PDBSET (CCP4)

Biochem Soc Trans 1:1179-1182 Varandani PT, Nafz MA, Chandler ML (1975) Interaction of insu- lin analogs, glucagon, growth hormone, vasopressin, oxytocin, and scrambled forms of ribonuclease and lysozyme with gluta- thione-insulin transhydrogenase (thiol: protein-disulfide oxidore- ductase): dependence upon conformation