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LXR agonists, such as RGX-104 and GW3965, reduce MDSC levels by activating the LXR/ApoE axis and reversing cholesterol transport, thereby improving the anti-tumor response of T cells in preclinical and clinical settings (NCT02922764) in various treatment-refractory tumors, resensitizing patients to anti-PD1 therapy (97)

SzewczykBPochwatBMuszyskaBOpokaWKrakowskaARafao-UliskaAet alAntidepressant-like activity of hyperforin and changes in BDNF and zinc levels in mice exposed to chronic unpredictable mild stress

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[DOI] [PMC free article] [PubMed] [Google Scholar] 7.De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P

Alzheimer disease: a challenge in managing with certain medicinal plantsa review