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TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models

For B/C: Gray bars indicate GSH/GSSG-Glo Assay only, whereas green bars indicate GSH/GSSG-Glo Assay multiplexed with the CellTox Green Cytotoxicity Assay

Sphingolipid metabolism also undergoes systematic rearrangement upon TLR4 activation, with newly synthesized species such as ceramide playing stage-specific regulatory roles during both pro-inflammatory and resolution phases in macrophages (145)

In support of this hypothesis, our lipidomic analysis evidenced an increase in triglycerides species

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