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The caution is with strong acids (glycolic, salicylic), which can deactivate peptides

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We also used MetaboAnalyst v5.0 (Xia Lab @ McGill University, Montreal, QC, Canada) [30] to identify the metabolites that contribute to group separation using Partial Least Squares-Discriminant Analysis (PLS-DA), heat map, and pathway analysis

Liposomal glutathione can partially bypass this first-pass effect, as the liposomes protect the glutathione from immediate metabolism