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Exposure to allergens, pollutants, respiratory infections, and stress can trigger immune responses, leading to airway inflammation

High glucose-induced endothelial STING activation inhibits diabetic wound healing through impairment of angiogenesis

To be beneficial, the inflammatory reaction must be acute, destroying an injurious agent within a short period of time and in a localized area, while inducing an immune response

Cells generate localized ROS near the nuclear envelope (NOX isoforms), the outer mitochondrial membrane (MAO facing the cytosol) and cytosolic dehydrogenase complexes adjoining the nucleus (Kaludercic et al

However, when it was tested in humans, it worsened stroke outcome and was associated with ICH, cardiac arrest, and meningitis [113,129]