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Erastin impairs cystine uptake through system Xc, leading to decreased GSH levels and reduced GPX4 activity, which weakens cellular antioxidant defenses, increases lipid ROS and induces ferroptosis

The development of venous thrombosis is also affected by ROS, which influence the formation and degradation of thrombus through the coagulation pathway, fibrinolysis, and effector cells including red blood cells and platelets 28,29

Benzyl alcohol works best under controlled and stable conditions

Adverse effects of VPA overdose, lethargy, coma, and respiratory depression, are caused not only by the drug itself but also by active metabolites formed via - and -oxidation

Potential objectives, dosage, and frequency are defined individually with the prescribing physician