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1,2 The IGFBPs may modulate the action of IGFs in several different ways: Inhibitory Model - IGFBPs prevent IGF/receptor association Enhancing Model - IGFBPs transport IGFs and facilitate binding with IGF receptors IGF Receptor-Independent Model - Product of direct IGFBPs/IGFBP receptor interaction Proteolytic Cleavage of IGFBP - Cleaved into lower affinity fragments which increases freely circulating, bioavailable IGF IGF-1 IGF-1 (Somatomedin C) is one of several growth factors necessary for normal human development

Sakai D, Mochida J, Yamamoto Y, Nomura T, Okuma M, Nishimura K, Nakai T, Ando K, Hotta T: Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration