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Using averaged metrics from our laboratory records where adult, male rats weighed 300 grams and consumed 22 grams of chow per day, we modified AIN-76A Purified Rodent Diet (Dyets, Inc., Bethelehem, PA) with 4.0% NaCl and 0.82 grams of Protandim per kilogram of chow, for a final dose of approximately 60.5 mg/kg/day or 450 mg/m 2

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The IV delivers these essential nutrients directly into the bloodstream, bypassing the digestive system for immediate and complete absorption

Cellular GSSG accumulation is limited by the fact that cells employ multiple redundant reductive pathways to reduce cytosolic GSSG or to actively export GSSG to the extracellular environment, for example by MRP1 in mammalian cells or to alternative subcellular compartments, for example by Ycf1 in yeast [21, 59]

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