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doi: 10.1038/nature08514 12 GosseltHRGriffioenPHvan ZelstBDOosteromNde JongeRHeilSGet al

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Methods The present review unveils a diverse chemical space including synthetic sulphonamides, sulphamates, sulfamides and many natural bioactive molecules which selectively inhibit the mitochondrial isoform CAVA/CAVB with an emphasis on major state-of-art drug design strategies

Average time from positive AMA result to PBC diagnosis was 94 days

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