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Oral F.n translocate to the intestine by resisting the acidic environment at pH 1.5 owing to the presence of erucic acid in its cell membrane, which is regulated by FnFabM, increasing its colonization efficiency in the stomach and jejunum of mice ( Parvimonas micra was found to translocate from the subgingival sulcus of the human oral cavity to colorectal adenocarcinoma, likely migrating in a synergistic consortium with other periodontal bacteria ( Klebsiella , Streptococcus , and Veillonella , can endure harsh acidic environments and migrate to the intestine, particularly in individuals with weakened oralgut chemical barriers (bile and gastric acid), such as infants, people with gastrointestinal disease, individuals using proton-pump inhibitors (PPIs), and elderly people (Xu et al., 2025)

Each guide includes the clinical trial titration used in published studies

158 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19)

382 Lui CC, Chen CL, Cheng YF, Lee TY