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Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking

The peptide derives from a larger protein naturally present in the stomach that helps maintain gastrointestinal integrity

Risk factors include: Celiac disease Pancreatic insufficiency Gallbladder or bile flow problems Cholestatic liver disease Cystic fibrosis Short bowel syndrome Bariatric surgery Chronic diarrhea Very low-fat diets If a patient has neuropathy, ataxia, balance problems, and evidence of fat malabsorption, vitamin E should be checked

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