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This initial work set the stage for subsequent studies to explore redox-sensitive targets in skeletal muscle

Chemotherapy drugs known to cause CIPN include platinum compounds (eg, oxaliplatin, cisplatin), taxanes (eg, paclitaxel, docetaxel), vinca alkaloids (eg, vincristine, vinorelbine), the immunomodulatory agent thalidomide (Thalidomid), and the proteasome inhibitor bortezomib (Velcade) (Loprinzi, Lacchetti 2020

Despite targeting both isoforms of GLS1, when CB-839 was tested against a panel of breast cancer cells, its effectiveness was limited to triple-negative breast cancer cells, which have elevated GAC expression and activity compared to receptor-positive cells (Gross et al, 2014)

Wang, Z., Zhao, C

Drug Metab Rev 38 , 651675 (2006)