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Gencheva, R

Resistance to osimertinib, a third-generation tyrosine kinase inhibitor targeting EGF receptor used as first-line therapy for patients with non-small cell lung cancer (NSCLC) harboring mutant EGFR, is mediated by IGF-1R signaling activated by IGF-2 in NSCLC cell lines (41)

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Working with the flood, rather than against it, may serve people better in the long run

Finally, to comprehensively assess the long-term effects of HCA on the liver and kidneys, we continued administering HCA (4 g/kg/d) by gavage once daily for one year following the completion of the 28-day modeling period