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The widely used 3xTg mouse model, which contains three mutations associated with familial Alzheimers disease, can display anxiety-like behaviors through behavioral paradigms such as the OFT and EPM test as early as 2 months of age (Paciello et al., 2021)

Jun 25 2015;7(7):714-719

Several phytochemical nanoformulations, such as paclitaxel (Abraxane ), irinotecan (Onivyde ), vinorelbine (NanoVNB ), vincristine (Marqibo ), and docetaxel (DoceAqualip ), are already FDA-approved for cancer therapy (Dhupal and Chowdhury, 2020), while multiple curcumin-, camptothecin-, ursolic acid-, mangiferin-, and quercetin-based platforms are undergoing clinical evaluation in liposomal, polymeric, micellar, and plant-derived nanocarriers (Devan et al., 2023