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Zur Erhaltung der Funktionalitt vieler, vielleicht aller Enzyme des Zellstoffwechsels, zur Verhinderung oxidativer Vernderungen ihrer katalytischen und allosterischen Zentren, zur Erhaltung einer optimalen Konformation ist das reduktive Potential des reduzierten Glutathions, d.h

doi: 10.1016/j.cell.2011.02.013 Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, Dayton BD, Ding H, Enschede SH, Fairbrother WJ, Huang DC, Hymowitz SG, Jin S, Khaw SL, Kovar PJ, Lam LT, Lee J, Maecker HL, Marsh KC, Mason KD, Mitten MJ, Nimmer PM, Oleksijew A, Park CH, Park CM, Phillips DC, Roberts AW, Sampath D, Seymour JF, Smith ML, et al

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however, with the exception of a few side effects, no serious toxicities have been recorded for them

The recombinant vectors were then transfected into cells, which were cultured in medium containing 4 mM or 0 mM Gln, respectively, followed by detection of luciferase activity