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Furthermore, deletion of Rtt109, the main acetyltransferase targeting this residue, shortens yeast lifespan, an effect also observed when deleting the H3K56-associated deacetylases Hst3 and Hst4 ( H3K79 H3K79, just like other lysine residues, can exist in one of three possible methylated forms: mono, di or trimethylated, which are involved in many cellular pathways, including transcription regulation, telomeric silencing, cell-cycle checkpoint, DNA repair, and cellular development (Rhie et al., 2013), mutating the lysine residue into glutamic acid (H3K79E) has an evident reduction in replicative lifespan (Sen et al., 2015)

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In line with CNS inflammation, prolonged microglial activation has also been reported in the brains of mice latently-infected with HSV, as indicated by high MHC class-II expression levels in CD45 int CD11b + cells up to 30 days post-infection (Figure 3B

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