Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan cit Contains an E3 ligase ligand

Contains an E3 ligase ligand substituted with piperazine

Product Name Pomalidomide-C6-Br Synonyms Pomalidomide-4'-C6-Br CAS Number 2355289-53-9 Related CAS Molecular Formula C19H22BrN3O4 Molecular Weight 436

Product Name 6-FAM PEG3 alkyne Synonyms CAS Number N/A Related CAS Molecular Formula C30H27NO9 Molecular Weight 545

S)-AHPC-CO-PEG5-C2-acid Synonyms CAS Number 2172820-14-1 Related CAS Molecular Formula C36H54N4O11S Molecular Weight 750

Product Name Thalidomide-C6-Br Synonyms Thalidomide-4'-C6-Br CAS Number n/a Related CAS Molecular Formula C19H21BrN2O4 Molecular Weight 421

Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan cit Contains an E3 ligase ligandSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC