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However, it is unknown whether the same effect would be observed in older adults with moderate milk intake or whether consuming more than 3 cups/day would provide added benefit

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Mitochondrial-dependent apoptosis is tightly linked to reactive oxygen species (ROS) levels, with elevated ROS leading to mitochondrial dysfunction and triggering the apoptotic cascade

The increased tissue biopterin levels were predominantly comprised of BH4, but analogous to the in vitro experiments, the increase in tissue BH4 was markedly inhibited by pretreatment with 10 mg/kg methotrexate before administration of either sepiapterin, BH2 or BH4