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Monzel et al., 2023), and thereby exacerbates neurodegenerative pathologies (Burt et al., 2015

Elevated plasma MDA levels may denote increased oxidative damage in the lungs, suggesting its utility as a biomarker for assessing COPD severity and progression

doi:10.1001/jamaoto.2018.2875

Furthermore, studies suggest that these alkaloids may also directly induce programmed cell death in neurons and glial cells via activation of the PPAR/NF-B/caspase-3-dependent apoptotic pathway, offering a novel explanation for their potential long-term or subacute neurotoxic effects [42]

Since then, a number of preclinical studies have examined its possible impacts on inflammation, gastrointestinal health, and tissue repair