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We found that BSO strongly enhances erastin-induced cell death, and the joint cytotoxicity of BSO + erastin can be effectively rescued by Fer-1, DFO and NAC, or by PDI inhibitors

Hallmark pathological features of AD are the accumulation of A plaques and neurofibrillary tangles composed of hyperphosphorylated tau proteins (Islam et al., 2025)

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Additionally, lycopene has been observed to influence the permeability of the bloodbrain barrier, which may be compromised in certain neurological conditions [126]