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A diagnosis of GSSD was finally made based on intractable metabolic acidosis, jaundice, hemolytic anemia, hyperbilirubinemia, massive 5-oxoprolinuria, and the presence of compound heterozygous variants in GSS

Glutathione is a peptide found in plants and animals

Recent studies also show that -sitosterol suppresses pro-survival signaling cascadesfor instance, an oxidized -sitosterol derivative significantly downregulated phosphorylated ERK1/2 and NF-B p65 levels, leading to increased ceramide accumulation and apoptosis in breast and liver cancer cells (97)

The model intracellular concentration of SAH declines under severe oxidative stress while in patients the average concentration of SAH in the blood went up 2449%

Marhaeny HD, Pratama YA, Rohmah L, Kasatu SM, Miatmoko A, Khotib J (2023) Development of gastro-food allergy model in shrimp allergen extract-induced sensitized mice promotes mast cell degranulation