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Unlike RPE cells, astrocytes are metabolically flexible (128) and neurons can easily switch to glycolysis (129) to ensure adequate ATP for maintaining proteostasis and preventing aberrant aggregation of elevated APOE2 condensates that also promote A elimination

Kurtoglu, A

However, the clinical utility of current antifungal therapies is hindered by challenges such as the emergence of drug resistance, limited antifungal spectra, and adverse side effects

This unique environment promotes hemoglobin S polymerization and erythrocyte sickling, predisposing patients with sickle cell disease to microinfarctions and renal papillary necrosis

K., Ng, S., Hostetter, G., Azam, S