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Pyridoxine facilitates GSH synthesis via the PKM2-Nrf2 pathway First, we performed an initial screen of 863 natural products purchased from TargetMol by intrinsic tryptophan differential scanning fluorimetry (nanoDSF) to explore molecules that may directly bind with PKM2

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Control-combination group displayed similar cellular density with no degenerative changes compared to the control group (Figure 3D)

However, this augmented pool of OPC failed to differentiate into mature oligodendrocytes and to enhance remyelination, probably due to induction of apoptosis in these cells by exogenously administered BMP4