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These scientists concluded as follows: Although there are many opinions about the risks or benefits of antioxidant supplementation, the only supportable conclusions based on the present research are that there is no evidence of antioxidant supplementation causing harm alongside cancer therapy, except for smokers undergoing radiotherapy. The caveat for smokers is based on a trial in head and neck cancer patients in which supplementing with alpha-tocopherol and beta-carotene during radiotherapy had a negative impact on rates of cancer recurrence and death in participants who smoked during the trial (Meyer 2008)

Insufficient levels of B12 can lead to diminished nerve function

These data show a non-significant ( p = 0.11) increase in insulinogenic index at 12 weeks that transitions to lower insulin secretion with mild beta cell ER stress in later life, compensated by increased glucose disposal

This is consistent with a study showing that the mean level of copper in the serum was higher in pregnant Iranian adolescents with depression than in those without depression (Bahramy et al., 2020)

Recent research has highlighted the potential for microbiome-based therapeutic strategies, such as probiotics, prebiotics, fecal microbiota transplantation (FMT), and dietary modifications, to restore microbial balance and alleviate disease symptoms