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Nat Metab 4 , 1516 (2022)

As our expectations, our result showed MMP-9 had a significant increase in the CS group

In animal models, DFO treatment decreased AD hallmarks, iron overload, iron-induced kinase activity [cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase 3 (GSK3)], mitochondrial dysfunction, synaptic loss, and neuronal damage (Sripetchwandee et al., 2016)