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This is not necessarily bad

Avoid self-dosing or altering dosages without professional guidance

While vitamin B12 supports cellular energy metabolism, supplementing B12 in a patient who is not deficient does not increase metabolic rate or cause fat loss

Although these symptoms improved with continued treatment, they initially worsened, indicating that neurological side effects can occur during the course of treatment

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists