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Moreover, signaling of lactate on these plasticity-related genes was intracellular, since the MCT blocker UK5099 abolished this effect

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Cancer patients often have depleted glutathione levels, especially after chemotherapy

First, at the mechanistic level, single-cell spatial transcriptomics and metabolomics should be used to map ferroptosis pathways in nigral dopaminergic neurons, astrocytes, and microglia, with emphasis on the interplay between NCOA4-mediated ferritinophagy and -synuclein degradation, to build a dynamic model linking iron dysregulation, proteotoxic stress, and cell death