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Rich lipofuscin granules have been observed in lymphocytes from aged mice, and it is known that lipofuscin may act as a danger signal, stimulating the release of pro-inflammatory chemokines and cytokines and activating macrophages, thereby leading to a chronic oxidative-inflammatory process 52

IL-17 plays an important role in regulating mycobacterium-induced inflammation and establishing homeostasis ( M

Additionally, the acute induction of GzmB contributes to fulminant hepatitis, a rapidly developing and lethal syndrome (143)

In endometriosis, impaired endometrial receptivity arises from interconnected mechanisms involving defective decidualization, altered immune cell populations, and a disrupted endometrial environment, collectively contributing to implantation failure

Res ., 38 (2), 159165