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However, the protective effects of GA on liver diseases and the underlying mechanisms remain unclear

References Holland, A

Small molecules directly targeting the clock proteins offer the potential to directly manipulate endogenous circadian rhythm to improve clock-regulated output processes, as well as to treat diseases associated with clock misalignment (for a comprehensive review on the topic see 135

In the inhibitor experiments, blocked transporters are shown above the bar, active transporters within the bar

Moreover, the tumor microenvironment (TME) in HCC is enriched with M2-polarized tumor-associated macrophages (TAMs), a dominant immunosuppressive population that promotes NK cell dysfunction and exhaustion [5, 11, 12]