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Blood-Brain Barrier Penetration and CNS Distribution Achieving sufficient CNS concentrations is a critical pharmacokinetic requirement for a procognitive compound, and Dihexa's peptidomimetic design addresses this challenge

These highly damaging free radicals further injure the mitochondrial membranes and DNA, creating a vicious cycle of oxidative stress and energy failure

tumour necrosis factor-alpha (TNF-) and interleukin-6 (IL-6), had decreased from baseline by 8.3%35% and 22%28.3%, respectively

PMID: 41699354

Most interestingly, accumulating evidence suggests that an Ang system like peripheral RAS is present in the brain and spinal cord, where angiotensinogen, Ang I, Ang II, ACE, AT 1 and AT 2 receptors, and cathepsin D, a renin-like enzyme, are detectable 5