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Alternatively, in the absence of GSH de novo synthesis, mosquito stages of Plasmodium may simply fail to deal with the intrinsic increase in oxidative stress associated with the endogenous accumulation of ROS by-products of cellular metabolism during ookinete and sporogonic development

Jpn J Pharmacol

JBT, JZ, and SEW received grants from the NIH, including 1 R01 AI145406-01A1, 5 P01 AI106684, and U10 HL109152, and donations from the Dellenback Fund

Taken together, the findings suggest that BA enhances astrocytosis in response to KA-induced neuronal cell death which may contribute to neuroprotection and reduced epileptic seizures