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Its been around for centuries, tracing back to Indigenous tribes in the Americas who used ground tobacco leaves for spiritual and ritual purposes

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N-nitrosamino acids [includes N-nitrososarcosine, 3-(methylnitrosamino) propionic acids and 4-(methylnitrosamino) butyric acids] and volatile N-nitrosamines [includes N-nitrosodimethylamine, N-nitrosopyrrolidine, N-nitrosopiperidine and N-nitrosomorpholine] are other classes of nitroso compounds present in ST products (International Agency for Research on Cancer, 2007, Kaur et al., 2018, Hecht, 2019)